Description

1-Chloro-2-Fluoro-3,5-Bis-(Trifluoromethyl)Benzene is a highly fluorinated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring multiple fluorine atoms and a reactive chlorine substituent, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorine-based drug discovery programs targeting CNS, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the introduction of fluorine atoms enhances biological activity, stability, and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, where its structure contributes to desired dielectric anisotropy and thermal stability.
• Polymer & Specialty Chemicals: Employed in the synthesis of fluorinated monomers and polymers, leading to materials with enhanced chemical resistance, low surface energy, and improved weatherability.
• Cross-Coupling Reactions: The chlorine atom is amenable to various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for constructing complex biaryl systems.
• Fluorine-18 Radiochemistry: A potential precursor for the synthesis of Positron Emission Tomography (PET) tracers, leveraging its fluorinated backbone.

Basic Information

Product Name	1-Chloro-2-Fluoro-3,5-Bis-(Trifluoromethyl)Benzene
CAS No.	1099597-46-2
Molecular Formula	C9H2ClF7
Molecular Weight	266.55 g/mol
Synonyms	3,5-Bis(trifluoromethyl)-1-chloro-2-fluorobenzene; 2-Fluoro-1-chloro-3,5-bis(trifluoromethyl)benzene; 1-Chloro-2-fluoro-3,5-di(trifluoromethyl)benzene; 3,5-Bis(trifluoromethyl)-2-fluorochlorobenzene; 2-Fluoro-α,α,α,α',α',α'-hexamethyl-1,3-benzenedicarbonyl trichloride (related precursor); Benzene, 1-chloro-2-fluoro-3,5-bis(trifluoromethyl)-; 1099597-46-2 (CAS Index Name)
EINECS	Contact for details

Quality Control

Our production of 1-Chloro-2-Fluoro-3,5-Bis-(Trifluoromethyl)Benzene adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including GC, HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP and ISO 9001 standards for pharmaceutical and industrial applications, ensuring full traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and potential concentration changes. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure (¹H & ¹⁹F NMR)
Purity (GC)	≥ 98.0% (Area %)
Water Content (KF)	≤ 0.1%
Residue on Ignition	≤ 0.1%
Related Substances (GC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.