Description

3-Chloro-2,6-Difluorobenzotrifluoride is a high-value fluorinated aromatic building block, distinguished by its unique combination of halogen substituents. This compound is critical for introducing specific steric and electronic properties into advanced molecular architectures. It is primarily sought after by R&D chemists and process engineers in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex molecules in drug discovery and development, particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Active Ingredient Synthesis: Used in the manufacture of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl and halogen groups enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a foundational component in the production of specialty chemicals for electronic displays and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifier: Imparts desirable properties such as chemical resistance, thermal stability, and low surface energy into high-performance polymers and coatings.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring new fluorination methodologies and the effects of fluorine substitution.

Basic Information

Product Name	3-Chloro-2,6-Difluorobenzotrifluoride
CAS No.	1099597-36-0
Molecular Formula	C7H2ClF5
Molecular Weight	216.54 g/mol
Synonyms	1-Chloro-2,6-difluoro-3-(trifluoromethyl)benzene; 2,6-Difluoro-3-(trifluoromethyl)chlorobenzene; 3-Chloro-2,6-difluoro-α,α,α-trifluorotoluene; 2,6-Difluoro-α,α,α-trichloro-m-xylene (obsolete); 3-(Trifluoromethyl)-2,6-difluorochlorobenzene; Benzene, 1-chloro-2,6-difluoro-3-(trifluoromethyl)-; C7H2ClF5
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-2,6-Difluorobenzotrifluoride is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and fluorides. Recommended storage temperature is between 2°C and 25°C. The container must be kept tightly sealed to prevent moisture ingress and potential decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.