Description

1-Ethynyl-2,4,5-Trifluorobenzene is a high-value fluorinated aromatic building block featuring an ethynyl group. This compound is critical for the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research, where its unique trifluoromethyl and alkyne functionalities enable precise structural modifications. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), especially for fluorine-containing drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or building block for synthesizing specialized polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The ethynyl group makes it an excellent substrate for Sonogashira, Click chemistry, and other palladium-catalyzed cross-coupling reactions to create complex molecular architectures.
• Fluorine Chemistry Research: An essential reagent for academic and industrial research exploring new methodologies in organofluorine chemistry.
• Ligand and Catalyst Development: Utilized in the design and synthesis of novel ligands and catalysts for asymmetric synthesis and other catalytic processes.

Basic Information

Product Name	1-Ethynyl-2,4,5-Trifluorobenzene
CAS No.	1097874-78-6
Molecular Formula	C8H3F3
Molecular Weight	162.11 g/mol
Synonyms	2,4,5-Trifluoroethynylbenzene; Ethynyl-2,4,5-trifluorobenzene; 2,4,5-Trifluoro-1-ethynylbenzene; 1-Ethynyl-2,4,5-trifluorobenzene; (2,4,5-Trifluorophenyl)acetylene; 2,4,5-Trifluorophenylacetylene
EINECS	Contact for details

Quality Control

Our 1-Ethynyl-2,4,5-Trifluorobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.