Description

5-Fluoro-1,2,3,4-Tetrahydroquinolin-4-One is a high-purity fluorinated heterocyclic building block of significant importance in advanced organic synthesis. This compound serves as a critical intermediate for the development of novel pharmaceutical candidates and agrochemicals, enabling the introduction of the quinoline scaffold with a strategic fluorine substituent. It is primarily utilized by research institutions and fine chemical manufacturers engaged in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of bioactive molecules, particularly in drug discovery programs targeting CNS disorders, oncology, and anti-infective agents.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and pesticides where the fluorinated quinoline structure imparts desired biological activity.
• Material Science Precursor: Serves as a building block for creating specialized organic ligands, fluorophores, and advanced polymeric materials.
• Academic & R&D: Employed in universities and contract research organizations (CROs) for methodological studies and exploring new chemical spaces in heterocyclic chemistry.
• Ligand Synthesis: Useful for constructing complex chelating agents in catalysis and coordination chemistry.

Basic Information

Product Name	5-Fluoro-1,2,3,4-Tetrahydroquinolin-4-One
CAS No.	1095270-78-2
Molecular Formula	C9H8FNO
Molecular Weight	165.17 g/mol
Synonyms	5-Fluoro-4-oxo-1,2,3,4-tetrahydroquinoline; 4(1H)-Quinolinone, 5-fluoro-1,2,3,4-tetrahydro-; 5-Fluoro-1,2,3,4-tetrahydro-4-quinolinone; 5-Fluoro-4-hydroxyquinoline (tautomer); 5-Fluoro-4-quinolone; 5-F-THQ-4-One; 1095270-78-2; 5-Fluoro-1,2,3,4-tetrahydroquinolin-4-ol (tautomeric form)
EINECS	Contact for details

Quality Control

Our 5-Fluoro-1,2,3,4-Tetrahydroquinolin-4-One is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of GMP and ISO standards for fine chemical production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.