Description

Arq 621 is a potent and selective small molecule inhibitor targeting the cell cycle checkpoint kinase, Wee1. This compound is a critical research tool for studying DNA damage response pathways and cell cycle regulation in oncology and molecular biology. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in cancer drug discovery and preclinical development.

Application

• Oncology Research: Used as a key pharmacological probe to investigate the role of Wee1 inhibition in sensitizing cancer cells to DNA-damaging agents.
• Drug Discovery: Serves as a reference standard and lead compound in the development of novel anti-cancer therapeutics targeting cell cycle checkpoints.
• Biochemical Assays: Employed in high-throughput screening (HTS) and in vitro kinase assays to evaluate Wee1 activity and inhibitor potency.
• Cell Biology Studies: Facilitates research into cell cycle progression, DNA replication stress, and mechanisms of apoptosis.
• Combination Therapy Studies: Investigated for its potential synergistic effects when used alongside chemotherapy or radiotherapy in preclinical models.

Basic Information

Item	Detail
Product Name	Arq 621
CAS No.	1095253-39-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	ARQ-621; ARQ 621; Wee1 Inhibitor ARQ-621; 2-Pyrimidinamine, 4-[4-[(2S)-2-methyl-1-pyrrolidinyl]-6-[4-(1-methylethyl)-1-piperazinyl]-2-pyrimidinyl]-; 4-(4-((S)-2-Methylpyrrolidin-1-yl)-6-(4-isopropylpiperazin-1-yl)pyrimidin-2-yl)pyrimidin-2-amine
EINECS	Contact for details

Quality Control

Our Arq 621 is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research use. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. Allow the product to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.