Description

2,6-Bis-Trifluoromethyl-Nicotinicacidethylester CAS NO 1095211-28-1 is a high-value fluorinated pyridine derivative, specifically an ethyl ester of a nicotinic acid analog. This compound is a critical advanced intermediate in modern organic synthesis, prized for the unique electronic and steric properties imparted by its trifluoromethyl groups. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical and agrochemical industries for constructing complex molecules, particularly in the development of active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in drug discovery programs targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antiviral compounds.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl groups enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis, enabling more efficient and selective chemical transformations.
• Material Science Research: Employed in the synthesis of fluorinated organic semiconductors, liquid crystals, and other functional materials that require specific electronic characteristics.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	2,6-Bis-Trifluoromethyl-Nicotinicacidethylester
CAS No.	1095211-28-1
Molecular Formula	C11H7F6NO2
Molecular Weight	299.17 g/mol
Synonyms	Ethyl 2,6-bis(trifluoromethyl)nicotinate; 2,6-Bis(trifluoromethyl)pyridine-3-carboxylic acid ethyl ester; 3-Pyridinecarboxylic acid, 2,6-bis(trifluoromethyl)-, ethyl ester; Ethyl 2,6-di(trifluoromethyl)nicotinate; 2,6-Di(trifluoromethyl)nicotinic acid ethyl ester; 1095211-28-1; Ethyl 2,6-bis(trifluoromethyl)-3-pyridinecarboxylate
EINECS	Contact for details

Quality Control

Every batch of 2,6-Bis-Trifluoromethyl-Nicotinicacidethylester is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the exacting standards required for research and process chemistry. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed results from HPLC, NMR, and GC-MS are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Store away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.