Description

Bix 02189 is a potent and selective small molecule inhibitor of MEK5, a key kinase in the ERK5 signaling pathway. This compound is a critical research tool for investigating cellular processes related to proliferation, differentiation, and survival, particularly in the context of cancer and cardiovascular biology. It is essential for pharmaceutical R&D, academic research, and biotechnology companies focused on targeted therapy development and signal transduction studies.

Application

• Biomedical Research: Used as a selective MEK5/ERK5 pathway inhibitor to study its role in cancer cell proliferation, angiogenesis, and tumor progression.
• Drug Discovery & Development: Serves as a key pharmacological tool and reference standard in high-throughput screening and lead optimization for oncology targets.
• Cellular Signaling Studies: Employed to elucidate the mechanisms of the ERK5 pathway in cellular differentiation, apoptosis, and stress responses.
• Cardiovascular Research: Investigated for its effects on cardiac hypertrophy, endothelial cell function, and vascular remodeling.
• Inflammatory Disease Models: Applied in research exploring the connection between the MEK5/ERK5 pathway and inflammatory conditions.
• Academic & Institutional Labs: A fundamental reagent for basic science research in molecular biology and biochemistry departments.

Basic Information

Product Name	Bix 02189
CAS No.	1094614-85-3
Molecular Formula	C₂₃H₂₀N₄O₃
Molecular Weight	400.43 g/mol
Synonyms	Bix02189; BIX 02189; 5-[(4-[(2,3-Dimethyl-2H-indazol-6-yl)methylene]-4H-pyrazol-3-yl]methylene]-1,3-thiazolidine-2,4-dione; MEK5 Inhibitor; ERK5 Inhibitor; 4-[(2,3-Dimethyl-2H-indazol-6-yl)methylene]-1-phenyl-1H-pyrazol-5(4H)-one (common misassignment, please verify); BIX-02189
EINECS	Contact for details

Quality Control

Every batch of Bix 02189 is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with standards expected for high-purity biochemical reagents used in research and development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.