Description

Bix 02188 is a potent and selective inhibitor of the MEK5/ERK5 signaling pathway, a key cellular cascade involved in regulating proliferation and survival. This compound is a critical research tool for investigating the role of ERK5 in various biological processes and disease models, particularly in oncology and cardiovascular research. It is essential for scientists and R&D teams in pharmaceutical development, academic research, and biotechnology who require high-purity biochemical tools for target validation and mechanistic studies.

Application

• Biochemical Research: Used as a selective pharmacological probe to inhibit the MEK5/ERK5 pathway in cell-based assays and in vitro studies.
• Oncology Research: Investigated for its effects on cancer cell proliferation, survival, and tumor growth in preclinical models, particularly in cancers where ERK5 signaling is implicated.
• Cardiovascular Disease Research: Applied in studies exploring the role of ERK5 in cardiac hypertrophy, heart failure, and vascular biology.
• Signal Transduction Studies: A key reagent for dissecting complex kinase signaling networks and understanding crosstalk between pathways.
• Drug Discovery & Development: Serves as a reference compound and a starting point for the design and screening of novel MEK5/ERK5 inhibitors.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental biological research and publication-related work.

Basic Information

Product Name	Bix 02188
CAS No.	1094614-84-2
Molecular Formula	C₂₃H₂₅N₅O₂
Molecular Weight	403.48 g/mol
Synonyms	Bix02188; BIX 02188; 5-[(4-[(2,3-Dimethyl-2H-indazol-6-yl)methylene]-4H-pyrazol-3-yl]methylene]-1,3-thiazolidine-2,4-dione; (5Z)-5-[(4-{[(2,3-Dimethyl-2H-indazol-6-yl)methylidene]amino}-1H-pyrazol-5-yl)methylidene]-1,3-thiazolidine-2,4-dione; ERK5 Inhibitor II; MEK5 Inhibitor
EINECS	Contact for details

Quality Control

Our Bix 02188 is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity confirmation and NMR for structural verification, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and batch-specific data is provided with every shipment to guarantee traceability and reproducibility for your experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.