Description

Ezetimibe-D4 is a high-purity, deuterium-labeled internal standard essential for precise quantitative analysis in pharmaceutical research and development. This stable isotope-labeled compound is critical for ensuring accuracy and reliability in mass spectrometry-based assays, particularly for pharmacokinetic and metabolic studies. It is primarily utilized by analytical laboratories, CROs, and pharmaceutical companies involved in the development and quality control of cholesterol-lowering medications.

Application

• Internal standard for the quantitative analysis of Ezetimibe and its metabolites using LC-MS/MS and GC-MS.
• Use in bioanalytical method development and validation for clinical and preclinical studies.
• Application in drug metabolism and pharmacokinetics (DMPK) research to track drug absorption and distribution.
• Essential reference material for ensuring regulatory compliance in pharmaceutical quality control laboratories.
• Used in the synthesis and characterization of deuterated pharmaceutical compounds.
• Supporting research into the mechanism of action and metabolic pathways of cholesterol absorption inhibitors.

Basic Information

Product Name	Ezetimibe-D4
CAS No.	1093659-89-2
Molecular Formula	C24H17D4F2NO3
Molecular Weight	409.42 g/mol
Synonyms	(3R,4S)-1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one-d4; Ezetimibe (phenyl-d4); Ezetimibe-d4; 1-(4-Fluorophenyl)-3(R)-[3(S)-(4-fluorophenyl)-3-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone-d4; Deuterated Ezetimibe; SCH 58235-d4
EINECS	Contact for details

Quality Control

Our Ezetimibe-D4 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, purity (by HPLC), isotopic enrichment, and other critical parameters. We support compliance with cGMP and ICH guidelines for pharmaceutical reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.