Description

2-Bromo-4-Fluoropyrimidine is a versatile and high-value halogenated pyrimidine building block essential for modern synthetic chemistry. Its core value proposition lies in enabling the precise introduction of bromine and fluorine substituents into complex molecular architectures, facilitating the development of novel compounds with tailored properties. This intermediate is critically needed by research and development teams in the pharmaceutical and agrochemical industries for applications in drug discovery, medicinal chemistry, and the synthesis of advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for oncology and antiviral drug candidates.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and pesticides, leveraging the fluorine atom for enhanced bioactivity and stability.
• Material Science Research: Serves as a building block for creating functionalized polymers, liquid crystals, and organic electronic materials.
• Medicinal Chemistry & SAR Studies: Enables structure-activity relationship (SAR) exploration by providing a handle for further functionalization via cross-coupling reactions (e.g., Suzuki, Sonogashira).
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and labeled compounds for biochemical and diagnostic research.
• Custom Synthesis & Contract Manufacturing: A critical raw material for fine chemical manufacturers specializing in custom synthesis and scale-up services for clients.

Basic Information

Product Name	2-Bromo-4-Fluoropyrimidine
CAS No.	1093407-50-1
Molecular Formula	C4H2BrFN2
Molecular Weight	176.97 g/mol
Synonyms	4-Fluoro-2-bromopyrimidine; 2-Bromo-4-fluoropyrimidine; 4-Fluoro-2-bromo-1,3-diazine; Pyrimidine, 2-bromo-4-fluoro-; Bromofluoropyrimidine
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-Fluoropyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistent quality suitable for demanding R&D and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.