Description

Rac1 Inhibitor Ii CAS NO 1090893-12-1 is a potent and selective small molecule inhibitor of the Rac1 GTPase, a key signaling node involved in cytoskeletal dynamics and cell proliferation. This compound is critical for researchers and developers targeting pathways related to cancer metastasis, neurological disorders, and inflammatory responses. It is an essential tool for high-value applications in pharmaceutical R&D, biochemical assay development, and academic research focused on cell signaling and migration studies.

Application

• Biochemical Research: Used as a selective probe to study Rac1-mediated signaling pathways, including actin polymerization, lamellipodia formation, and NADPH oxidase activation.
• Oncology Research: Investigated for its potential to inhibit cancer cell invasion, metastasis, and proliferation in various in vitro and in vivo models.
• Neuroscience Studies: Applied in research on neurological conditions where Rac1 activity is implicated, such as in synaptic plasticity and certain neurodegenerative diseases.
• Inflammation & Immunology: Utilized to modulate immune cell functions like phagocytosis and chemotaxis in studies of inflammatory diseases.
• Drug Discovery & Development: Serves as a lead compound or reference standard in high-throughput screening (HTS) and structure-activity relationship (SAR) studies for novel therapeutics.
• Cell Biology Assays: A key reagent in functional cellular assays to dissect the role of Rac1 in cell motility, morphology, and division.

Basic Information

Product Name	Rac1 Inhibitor Ii
CAS No.	1090893-12-1
Molecular Formula	C₂₀H₂₀N₄O₃
Molecular Weight	364.40 g/mol
Synonyms	NSC 23766; 1,2,3,4-Tetrahydro-1-[(6,7-dimethoxy-2-methyl-4-quinazolinyl)amino]-6,7-dimethoxy-2-methylisoquinoline; Rac1 Inhibitor, NSC 23766; 6,7-Dimethoxy-2-methyl-1-[(6,7-dimethoxy-2-methyl-4-quinazolinyl)amino]-1,2,3,4-tetrahydroisoquinoline; EHT 1864 (Note: This is a distinct Rac inhibitor, often listed as a synonym in databases); Rac GTPase Inhibitor; CAS 1090893-12-1
EINECS	Contact for details

Quality Control

Our Rac1 Inhibitor Ii is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and potency. We adhere to relevant quality standards for research chemicals, ensuring reliable performance in sensitive biological assays.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Solubility	Soluble in DMSO, Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.