Description

4-(Chloromethyl)-2-Fluoro-1-(Trifluoromethoxy)Benzene is a high-value fluorinated aromatic building block essential for advanced organic synthesis. Its unique structure, featuring reactive chloromethyl and trifluoromethoxy groups, enables the precise introduction of fluorinated motifs into target molecules. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in CNS and oncology drug candidates.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides where the trifluoromethoxy group improves metabolic stability and bioavailability.
• Liquid Crystal Materials: Used in the synthesis of fluorinated components for advanced display technologies.
• Polymer Chemistry: Monomer or cross-linking agent for specialty polymers with specific chemical resistance and surface properties.
• Organic Electronics: Intermediate in the production of materials for organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Research: Versatile reagent for method development and exploring new fluorination reactions in academic and industrial laboratories.

Basic Information

Item	Details
Product Name	4-(Chloromethyl)-2-Fluoro-1-(Trifluoromethoxy)Benzene
CAS No.	1089333-51-6
Molecular Formula	C9H5ClF4O
Molecular Weight	240.58 g/mol
Synonyms	2-Fluoro-α-(chloromethyl)-4-(trifluoromethoxy)benzene; 1-Chloromethyl-2-fluoro-4-trifluoromethoxybenzene; 4-(Chloromethyl)-2-fluoro-1-(trifluoromethoxy)benzene; 2-Fluoro-4-trifluoromethoxybenzyl chloride; (2-Fluoro-4-(trifluoromethoxy)phenyl)methyl chloride; Benzene, 4-(chloromethyl)-2-fluoro-1-(trifluoromethoxy)-; α-Chloro-2-fluoro-4-trifluoromethoxytoluene
EINECS	Contact for details

Quality Control

Every batch of 4-(Chloromethyl)-2-Fluoro-1-(Trifluoromethoxy)Benzene is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the precise requirements for advanced synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to prevent degradation. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.