Description

Gsk1904529A is a potent and selective small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) tyrosine kinase, with the CAS registry number 1089283-49-7. This compound is a critical research tool for investigating cellular signaling pathways related to growth, proliferation, and survival, particularly in oncology research. It is essential for pharmaceutical R&D laboratories, academic institutions, and biotechnology companies focused on developing targeted cancer therapies and understanding metabolic disorders.

Application

• Biomedical Research: A key reagent for studying the role of IGF-1R signaling in cancer cell proliferation, metastasis, and resistance to chemotherapy.
• Drug Discovery & Development: Used as a reference standard and pharmacological tool in high-throughput screening and lead optimization for oncology targets.
• Mechanistic Studies: Enables the exploration of crosstalk between IGF-1R and other receptor tyrosine kinase pathways in metabolic and endocrine research.
• Preclinical Research: Employed in in vitro and in vivo models to validate IGF-1R as a therapeutic target and assess the efficacy of novel inhibitors.
• Signal Transduction Analysis: Facilitates the dissection of downstream effects on PI3K/Akt and MAPK/ERK pathways in various cell types.
• Academic & Contract Research: Serves as a critical compound for universities and CROs conducting fundamental and applied life science research.

Basic Information

Product Name	Gsk1904529A
CAS No.	1089283-49-7
Molecular Formula	C₂₄H₂₅N₅O₃
Molecular Weight	431.49 g/mol
Synonyms	GSK1904529A; GSK 1904529A; GSK-1904529A; 2-[4-(4-Cyano-2-fluorophenoxy)-2-fluorophenyl]-N-[2-(1H-imidazol-1-yl)ethyl]acetamide; IGF-1R Inhibitor (GSK1904529A); Insulin-like growth factor 1 receptor inhibitor GSK1904529A
EINECS	Contact for details

Quality Control

Our Gsk1904529A is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards. Our quality commitment supports reproducible and reliable experimental results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.