Description

Aripiprazole-D8 is a deuterated analog of the atypical antipsychotic drug Aripiprazole, specifically designed for use as an internal standard in quantitative bioanalytical methods. This high-purity, isotopically labeled compound is essential for ensuring the accuracy and reliability of pharmacokinetic, metabolism, and forensic studies by compensating for matrix effects and instrument variability. It is a critical tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory bodies engaged in drug development and quality control.

Application

• Quantitative Bioanalysis: Serves as a stable isotope-labeled internal standard in LC-MS/MS and GC-MS assays for the precise quantification of Aripiprazole and its metabolites in biological matrices (plasma, serum, urine).
• Pharmacokinetic & Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Forensic & Clinical Toxicology: Used in method development and routine testing for the accurate determination of Aripiprazole levels in forensic and therapeutic drug monitoring applications.
• Drug Impurity & Degradation Profiling: Aids in the identification and quantification of process-related impurities or degradation products in pharmaceutical formulations.
• Method Development & Validation: Critical for developing, optimizing, and validating robust analytical methods compliant with FDA, EMA, and ICH guidelines.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-accuracy IDMS techniques, which are considered a gold standard for reference measurement procedures.

Basic Information

Product Name	Aripiprazole-D8
CAS No.	1089115-06-9
Molecular Formula	C23H19D8Cl2N3O2
Molecular Weight	~ 452.42 g/mol
Synonyms	7-{4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy}-3,4-dihydro-2(1H)-quinolinone-D8; 7-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one-D8; Aripiprazole (D8); Deuterated Aripiprazole; Aripiprazole-d8 Internal Standard
EINECS	Contact for details

Quality Control

Every batch of Aripiprazole-D8 is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity to meet the exacting demands of analytical reference standards. Comprehensive testing includes assay, isotopic enrichment (D-content), and identification by spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.