Description

2-Methoxyethane-1-Sulfonyl Fluoride is a specialized organosulfur compound featuring a sulfonyl fluoride group, a highly reactive and versatile functional group in modern synthetic chemistry. Its primary value lies in its role as a key building block and reagent for the synthesis of sulfonamides and other sulfonyl-containing molecules, which are prevalent in pharmaceuticals and agrochemicals. This compound is particularly relevant for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require high-purity intermediates for drug discovery and process development.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for creating sulfonamide-based drugs with potential antibacterial, diuretic, or anticancer properties.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the sulfonyl moiety imparts specific biological activity.
• Chemical Biology & Proteomics: Acts as a reactive handle in activity-based protein profiling (ABPP) and the development of covalent inhibitors, leveraging the selectivity of the sulfonyl fluoride group for serine hydrolases.
• Polymer & Materials Science: Employed as a monomer or cross-linking agent in the production of specialty polymers, such as sulfonated polymers for ion-exchange membranes or high-performance materials.
• Sulfonylation Reagent: Functions as an efficient sulfonylating agent in organic synthesis to introduce the methoxyethylsulfonyl group into target molecules under mild conditions.
• R&D and Process Chemistry: Essential for medicinal chemistry programs and scale-up processes in contract research and manufacturing organizations (CROs/CMOs).

Basic Information

Product Name	2-Methoxyethane-1-Sulfonyl Fluoride
CAS No.	1087410-86-3
Molecular Formula	C₃H₇FO₃S
Molecular Weight	142.15 g/mol
Synonyms	2-Methoxyethanesulfonyl Fluoride; 2-Methoxyethylsulfonyl Fluoride; 1-Methoxy-2-fluoro sulfonylethane; Ethanesulfonyl Fluoride, 2-methoxy-; Methoxyethyl Sulfonyl Fluoride; MESF; 2-MESF; Glymesulfonyl Fluoride (derivative)
EINECS	Contact for details

Quality Control

Our 2-Methoxyethane-1-Sulfonyl Fluoride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and identity confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting key parameters such as assay, impurity profile, and water content. Our quality commitment aligns with the standards expected for advanced pharmaceutical intermediates, supporting our customers' regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 96.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.