Description

Rac Normetanephrine-D3 Hydrochloride CAS NO 1085333-97-6 is a deuterium-labeled internal standard critical for advanced analytical quantification. This high-purity compound is essential for ensuring the accuracy and reliability of mass spectrometry-based analyses. It is primarily utilized by pharmaceutical R&D laboratories, clinical research organizations, and forensic toxicology labs for precise measurement of normetanephrine and related catecholamine metabolites.

Application

• Quantitative Mass Spectrometry: Serves as a stable isotope-labeled internal standard (SIL-IS) for the accurate LC-MS/MS analysis of normetanephrine in complex biological matrices.
• Clinical Diagnostics & Research: Enables precise measurement of catecholamine metabolites for research into pheochromocytoma, paraganglioma, and other neuroendocrine disorders.
• Pharmacokinetic & Metabolism Studies: Used in ADME (Absorption, Distribution, Metabolism, Excretion) studies to track the metabolic fate of pharmaceuticals and endogenous compounds.
• Forensic Toxicology: Supports the confirmatory analysis of sympathomimetic amines and their metabolites in forensic investigations.
• Method Development & Validation: A key reagent for developing and validating robust, GLP-compliant bioanalytical methods in regulated environments.
• Quality Control in Pharmaceutical Manufacturing: Can be employed in impurity profiling and assay development for drug substances and products.

Basic Information

Item	Detail
Product Name	Rac Normetanephrine-D3 Hydrochloride
CAS No.	1085333-97-6
Molecular Formula	C9H8D3NO3 • HCl
Molecular Weight	233.69 g/mol (for monohydrochloride)
Synonyms	DL-Normetanephrine-d3 hydrochloride; (±)-Normetanephrine-d3 HCl; 3,4-Dihydroxyphenyl(d3)ethanolamine hydrochloride; 4-Hydroxy-3-methoxyphenyl(d3)ethanolamine hydrochloride; 3-O-Methyl-d3-adrenaline hydrochloride; 3-Methoxy-d3-adrenaline hydrochloride; NMN-d3 HCl; d3-Normetanephrine HCl
EINECS	Contact for details

Quality Control

Every batch of Rac Normetanephrine-D3 Hydrochloride is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We guarantee high chemical and isotopic purity to meet the exacting requirements of quantitative bioanalysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), isotopic enrichment, and other critical parameters is provided with each shipment to ensure full traceability and compliance with your method validation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (deuterium incorporation)	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.