Description

Quisinostat Hcl CAS NO 1083078-98-1 is a potent and selective histone deacetylase (HDAC) inhibitor, representing a key compound in the field of epigenetic research and targeted cancer therapy development. Its primary value lies in its ability to modulate gene expression by inhibiting Class I and II HDAC enzymes, which is a critical mechanism for inducing cell cycle arrest and apoptosis in malignant cells. This makes it an essential research chemical for pharmaceutical R&D teams, academic institutions, and biotechnology companies focused on oncology, hematology, and novel therapeutic discovery.

Application

• Oncology Research: A critical tool for studying the mechanisms of HDAC inhibition and its effects on tumor cell proliferation, differentiation, and death in various cancer models.
• Preclinical Drug Development: Serves as a reference standard and active pharmaceutical ingredient (API) intermediate in the development of new HDAC-targeted anticancer agents.
• Biochemical Assays: Used in high-throughput screening (HTS) and in vitro enzymatic assays to evaluate HDAC activity and inhibitor potency.
• Epigenetics Studies: Facilitates research into chromatin remodeling, histone acetylation dynamics, and their roles in gene regulation and disease.
• Combination Therapy Studies: Investigated in research settings for potential synergistic effects when used with other chemotherapeutic agents or novel modalities.
• Academic & Institutional Research: A key reagent for universities and research institutes exploring molecular pathways in cancer and other diseases linked to epigenetic dysregulation.

Basic Information

Product Name	Quisinostat Hcl
CAS No.	1083078-98-1
Molecular Formula	C24H27ClN4O3 • HCl
Molecular Weight	491.86 g/mol (for free base C24H27ClN4O3>)
Synonyms	JNJ-26481585 dihydrochloride; JNJ26481585; 2HCl; Quisinostat dihydrochloride; (2E)-N-Hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide dihydrochloride; HDAC Inhibitor JNJ-26481585; JNJ 26481585 2HCl
EINECS	Contact for details

Quality Control

Our Quisinostat Hcl is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency suitable for research and development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, and specifications can be tailored to meet specific project requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccants and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.