Description

5-Chloro-2-(Difluoromethoxy)Benzene-1-Sulfonyl Chloride is a high-purity, reactive sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a versatile handle for introducing the sulfonamide or sulfonate functional group, which is essential for modulating the biological activity and physicochemical properties of target molecules. This intermediate is primarily needed by R&D and production teams in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly for creating sulfonamide-based therapeutics with potential applications in oncology, virology, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the sulfonyl moiety enhances efficacy and selectivity.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers, coatings, and functional materials with specific surface properties.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes (ABPs) and other research tools for studying enzyme function and protein interactions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for fine chemical manufacturers offering bespoke synthesis services to clients in life sciences.

Basic Information

Item	Details
Product Name	5-Chloro-2-(Difluoromethoxy)Benzene-1-Sulfonyl Chloride
CAS No.	1082821-83-7
Molecular Formula	C7H4Cl2F2O3S
Molecular Weight	277.07 g/mol
Synonyms	5-Chloro-2-(difluoromethoxy)benzenesulfonyl chloride; 2-(Difluoromethoxy)-5-chlorobenzenesulfonyl chloride; 1-Chloro-4-(difluoromethoxy)-2-sulfonylchloridebenzene; Benzenesulfonyl chloride, 5-chloro-2-(difluoromethoxy)-; CAS 1082821-83-7
EINECS	Contact for details

Quality Control

Every batch of 5-Chloro-2-(Difluoromethoxy)Benzene-1-Sulfonyl Chloride is manufactured and tested under a strict quality management system. We guarantee high chemical purity and lot-to-lot consistency through rigorous analytical protocols including HPLC, GC, and NMR. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to ensure full traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.