Description

Kx2-391 (Mesylate) is a potent and selective small molecule inhibitor of Src family kinases, primarily known for its role in cancer research. This compound is a critical tool for investigating signaling pathways involved in cell proliferation, differentiation, and survival. It is essential for researchers and developers in the pharmaceutical and biotechnology sectors, particularly those focused on oncology and targeted therapy development.

Application

• Biochemical Research: A key reagent for studying Src kinase signaling pathways and their role in cellular processes.
• Oncology Research: Used in in vitro and in vivo studies to evaluate anti-proliferative effects on various cancer cell lines.
• Drug Discovery & Development: Serves as a reference standard and a lead compound in the development of novel kinase inhibitors.
• Cell Biology Studies: Applied to investigate the role of Src kinases in cell adhesion, migration, and cytoskeletal dynamics.
• Academic Research: Utilized in university and institutional labs for fundamental research in signal transduction.
• Preclinical Studies: Employed in animal models to assess pharmacokinetics, pharmacodynamics, and efficacy of related therapeutic candidates.

Basic Information

Product Name	Kx2-391 (Mesylate)
CAS No.	1080645-95-9
Molecular Formula	C₂₀H₂₀N₄O₃S • CH₄O₃S
Molecular Weight	476.56 g/mol
Synonyms	KX2-391; KX2-391 Mesylate; KX01; Tirbanibulin Mesylate; (2S)-N-(3,4-Dichlorophenyl)-1-(2-{[4-(2-pyridinyl)phenyl]amino}pyrimidin-4-yl)-4-piperidinecarboxamide methanesulfonate; 1-(2-{[4-(2-Pyridinyl)phenyl]amino}-4-pyrimidinyl)-4-[(2S)-2-[(3,4-dichlorophenyl)carbamoyl]piperidin-1-yl] methanesulfonate
EINECS	Contact for details

Quality Control

Our Kx2-391 (Mesylate) is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality guidelines to support the integrity of your research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.