Description

1-(3,5-Difluoropyridin-2-yl)ethanone is a high-purity fluorinated pyridine derivative, a crucial advanced intermediate in modern synthetic chemistry. Its value lies in its unique difluoropyridine scaffold, which is strategically important for modulating the physicochemical and biological properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients requiring specific fluorine substitution patterns.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in drug discovery programs targeting central nervous system (CNS) disorders, oncology, and anti-infective agents.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance metabolic stability and bioavailability.
• Material Science Precursor: Serves as a starting material for synthesizing specialized ligands, catalysts, and fluorinated organic frameworks used in advanced materials.
• Chemical Research & Development: Employed in academic and industrial R&D labs for method development, structure-activity relationship (SAR) studies, and the creation of novel chemical entities.
• Liquid Crystal & Electronic Chemical Intermediate: Can be utilized in the synthesis of fluorinated components for electronic materials and display technologies.

Basic Information

Product Name	1-(3,5-Difluoropyridin-2-yl)ethanone
CAS No.	1075756-90-9
Molecular Formula	C7H5F2NO
Molecular Weight	157.12 g/mol
Synonyms	2-Acetyl-3,5-difluoropyridine; 3,5-Difluoro-2-acetylpyridine; 1-(3,5-Difluoro-2-pyridinyl)ethanone; Ethanone, 1-(3,5-difluoro-2-pyridinyl)-; 2-Pyridinecarbonyl, 3,5-difluoro-; 3,5-Difluoropyridin-2-yl methyl ketone
EINECS	Contact for details

Quality Control

Our 1-(3,5-Difluoropyridin-2-yl)ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.