Description

E3 Ligase Ligand 10 is a high-purity, synthetic small molecule designed for targeted protein degradation research. This compound serves as a critical component in the development of Proteolysis-Targeting Chimeras (PROTACs), enabling the selective elimination of disease-causing proteins. It is essential for pharmaceutical R&D, biotechnology, and academic laboratories focused on advancing novel therapeutic modalities in oncology, neurodegenerative diseases, and beyond.

Application

• PROTAC Molecule Synthesis: A key ligand for constructing heterobifunctional PROTAC degraders that recruit E3 ubiquitin ligases.
• Chemical Biology Research: Tool compound for studying ubiquitin-proteasome system (UPS) pathways and protein homeostasis.
• Drug Discovery Platforms: Used in high-throughput screening and validation of novel protein degradation targets.
• Oncology & Immunology R&D: Enables the targeted degradation of oncoproteins and immune modulators for therapeutic development.
• Academic & Institutional Research: Fundamental research into the mechanisms and applications of induced proteolysis.
• Biopharmaceutical Manufacturing Support: Serves as a reference standard and intermediate in process development for targeted degraders.

Basic Information

Item	Details
Product Name	E3 Ligase Ligand 10
CAS No.	1073560-68-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	VH032; VHL Ligand VH032; (1S,4R)-4-(4-(((S)-2-Amino-3-methylbutanoyl)amino)benzyl)-N-(4-(4-methylthiazol-5-yl)benzyl)cyclohexane-1-carboxamide; E3 Ligase Ligand VH032; VHL Inhibitor VH032; VHL Ligand 10; VH-032; Ligand for Von Hippel-Lindau (VHL) E3 Ubiquitin Ligase
EINECS	Contact for details

Quality Control

Our E3 Ligase Ligand 10 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, critical for sensitive biological research. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant standards for research-grade biochemicals to support your discovery and development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. Allow the container to reach room temperature before opening to minimize moisture condensation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.