Description

3-Carboxy-5-Fluoropyridine-4-Boronic Acid is a high-value, multifunctional heterocyclic building block essential for modern synthetic chemistry. Its core value lies in the unique combination of a boronic acid group for Suzuki-Miyaura cross-coupling and a carboxylic acid moiety for further derivatization, enabling the rapid construction of complex molecular architectures. This compound is critically needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and insecticides where the fluoropyridine scaffold enhances biological activity and environmental stability.
• Material Science Building Block: Employed in the creation of organic electronic materials, metal-organic frameworks (MOFs), and functional polymers requiring precise molecular design.
• Chemical Biology & Proteomics: Serves as a versatile handle for bioconjugation and the development of molecular probes and enzyme inhibitors.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura cross-coupling to form biaryl and heterobiaryl bonds, a cornerstone reaction in medicinal chemistry.
• Library Synthesis for Drug Discovery: Enables high-throughput parallel synthesis for creating diverse compound libraries during hit identification and lead optimization phases.

Basic Information

Product Name	3-Carboxy-5-Fluoropyridine-4-Boronic Acid
CAS No.	1072952-47-6
Molecular Formula	C6H5BFNO4
Molecular Weight	184.92 g/mol
Synonyms	4-Borono-5-fluoro-3-pyridinecarboxylic Acid; 5-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinic Acid (Pinacol Ester precursor); 3-Carboxy-5-fluoropyridine-4-boronic Acid; 5-Fluoro-4-borononicotinic Acid; 4-Borono-5-fluoronicotinic Acid; 5-Fluoro-3-pyridinecarboxylic-4-boronic Acid; (5-Fluoro-3-carboxypyridin-4-yl)boronic Acid
EINECS	Contact for details

Quality Control

Our 3-Carboxy-5-Fluoropyridine-4-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF Titration)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.