Description

4-(Trifluoromethyl)Pyridine-3-Boronic Acid Hydrate is a high-value organoboron building block, specifically a pyridine-substituted boronic acid derivative. This compound is essential for modern synthetic chemistry, enabling the formation of carbon-carbon bonds via the versatile Suzuki-Miyaura cross-coupling reaction. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex molecules in the research and development of new active pharmaceutical ingredients (APIs), particularly those containing trifluoromethylpyridine motifs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and stability.
• Suzuki-Miyaura Cross-Coupling: Serves as a critical boron reagent for palladium-catalyzed coupling with aryl/heteroaryl halides to create biaryl and heterobiaryl structures.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Material Science Research: A building block for creating organic electronic materials, such as those used in OLEDs and semiconductors.
• Chemical Biology Probes: Useful for synthesizing tagged molecules and probes for studying biological systems and drug discovery.

Basic Information

Product Name	4-(Trifluoromethyl)Pyridine-3-Boronic Acid Hydrate
CAS No.	1072952-32-9
Molecular Formula	C6H5BF3NO2 • xH2O
Molecular Weight	190.92 (Anhydrous Basis)
Synonyms	[3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)pyridine] (Protected form); 5-(Trifluoromethyl)pyridine-3-boronic acid hydrate; 3-Borono-5-(trifluoromethyl)pyridine hydrate; (5-(Trifluoromethyl)pyridin-3-yl)boronic acid hydrate; 4-Trifluoromethyl-3-pyridineboronic acid hydrate; CAS 1072952-32-9
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and manufacturing. Each batch is analyzed using advanced techniques including NMR, HPLC, and mass spectrometry to confirm identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are available upon request. We adhere to a cGMP-compliant quality management system to ensure traceability and reliability for our global customer base.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 3.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.