Description

2,6-Difluoropyridine-3-Boronic Acid Hydrate is a high-value boronic acid derivative and a versatile building block in modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key synthon for constructing pyridine-based active pharmaceutical ingredients (APIs) and drug candidates, particularly in kinase inhibitor and CNS drug research.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides that incorporate the difluoropyridine motif for enhanced biological activity and stability.
• Suzuki-Miyaura Cross-Coupling: Serves as a critical boron-containing partner for palladium-catalyzed coupling with aryl/heteroaryl halides to create biaryl and heterobiaryl structures.
• Material Science Research: Employed in the synthesis of organic ligands for catalysis and as a precursor for functionalized polymers or liquid crystals.
• Chemical Biology & Diagnostics: Utilized in probe and sensor development where the boronic acid group enables specific molecular recognition.

Basic Information

Product Name	2,6-Difluoropyridine-3-Boronic Acid Hydrate
CAS No.	1072952-27-2
Molecular Formula	C5H5BF2NO3 (anhydrous basis)
Molecular Weight	175.91 g/mol (anhydrous)
Synonyms	(2,6-Difluoropyridin-3-yl)boronic acid hydrate; 3-Borono-2,6-difluoropyridine hydrate; 2,6-Difluoro-3-pyridineboronic acid hydrate; 2,6-Difluoropyridine-3-boronic acid, hydrate; 1072952-27-2; 2,6-Difluoro-3-pyridylboronic acid hydrate
EINECS	Contact for details

Quality Control

Our 2,6-Difluoropyridine-3-Boronic Acid Hydrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for water content, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.