Description

4-[(2',6'-Diisopropylphenoxy)Methyl]Phenylboronic Acid is a sophisticated, sterically hindered boronic acid derivative designed for advanced cross-coupling reactions, particularly in the synthesis of complex organic molecules. Its unique molecular architecture, featuring a bulky diisopropylphenoxy group, provides enhanced stability and selectivity, making it a critical reagent for constructing challenging chemical bonds. This high-value intermediate is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity building blocks for drug discovery and specialty chemical production.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds between aryl/heteroaryl halides and this boronic acid, crucial for synthesizing biaryl structures in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate Synthesis: Serves as a pivotal building block in the multi-step synthesis of novel drug candidates, especially those requiring sterically hindered biphenyl motifs.
• Agrochemical Active Ingredient Development: Used in the research and production of advanced herbicides, fungicides, and insecticides where specific aryl-aryl linkages are necessary for bioactivity.
• Ligand Synthesis for Catalysis: Employed as a precursor for creating specialized ligands used in homogeneous catalysis, enhancing reaction efficiency and selectivity.
• Advanced Material Precursors: Facilitates the creation of organic electronic materials, such as those used in OLEDs and organic photovoltaics, by enabling the construction of complex conjugated systems.
• Chemical Biology & Proteomics: Utilized in the development of chemical probes and affinity tags for studying protein function and interactions.

Basic Information

Product Name	4-[(2',6'-Diisopropylphenoxy)Methyl]Phenylboronic Acid
CAS No.	1072951-63-3
Molecular Formula	C20H27BO3
Molecular Weight	326.24 g/mol
Synonyms	[2,6-Bis(1-methylethyl)phenoxy]methyl]benzeneboronic Acid; 4-[(2,6-Diisopropylphenoxy)methyl]benzeneboronic Acid; B-[4-[[[2,6-Bis(1-methylethyl)phenyl]oxy]methyl]phenyl]boronic Acid; 4-(2,6-Diisopropylphenoxymethyl)phenylboronic Acid; (4-((2,6-Diisopropylphenoxy)methyl)phenyl)boronic Acid; B-[4-[(2,6-Di-iso-propylphenoxy)methyl]phenyl]boronic Acid; 4-[(2,6-Diisopropylphenoxy)methyl]phenylboronic Acid Pinacol Ester (protected form).
EINECS	Contact for details

Quality Control

Our production of 4-[(2',6'-Diisopropylphenoxy)Methyl]Phenylboronic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is fully characterized and undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent moisture absorption and decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.