Description

2-Chloro-3-Fluoropyridine-5-Boronic Acid is a high-value, multi-functional heterocyclic boronic acid building block essential for modern synthetic chemistry. Its primary commercial value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of pharmaceutical and agrochemical development. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides requiring specific pyridine-based scaffolds.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid reagent for palladium-catalyzed coupling with aryl/heteroaryl halides to create biaryl structures.
• Ligand and Catalyst Development: A precursor for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as those for OLEDs and conductive polymers.
• Chemical Biology Probes: Useful for creating tagged molecules and probes for studying biological pathways and target engagement.

Basic Information

Product Name	2-Chloro-3-Fluoropyridine-5-Boronic Acid
CAS No.	1072946-66-7
Molecular Formula	C5H4BClFNO2
Molecular Weight	174.36 g/mol
Synonyms	(2-Chloro-3-fluoropyridin-5-yl)boronic acid; 5-Borono-2-chloro-3-fluoropyridine; 2-Chloro-3-fluoro-5-pyridineboronic acid; 3-Fluoro-2-chloropyridine-5-boronic acid; 2-Chloro-3-fluoro-5-pyridinylboronic acid; Boronic acid, B-(2-chloro-3-fluoro-5-pyridinyl)-; 1072946-66-7
EINECS	Contact for details

Quality Control

Our 2-Chloro-3-Fluoropyridine-5-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.