Description

2-Chloro-5-Methoxypyridine-4-Boronic Acid is a versatile and high-value boronic acid derivative, serving as a critical building block in modern synthetic chemistry. Its primary value lies in its role as a key intermediate in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as those used in OLEDs and organic semiconductors.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized to create tagged molecules for studying biological pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds under cGMP conditions where applicable.

Basic Information

Product Name	2-Chloro-5-Methoxypyridine-4-Boronic Acid
CAS No.	1072945-98-2
Molecular Formula	C6H7BClNO3
Molecular Weight	187.39 g/mol
Synonyms	(2-Chloro-5-methoxypyridin-4-yl)boronic acid; 4-Borono-2-chloro-5-methoxypyridine; 2-Chloro-5-methoxy-4-pyridineboronic acid; 2-Chloro-5-methoxypyridine-4-boronic acid pinacol ester (common derivative); 2-Chloro-5-methoxy-4-pyridinylboronic acid; 4-Pyridineboronic acid, 2-chloro-5-methoxy-; B-(2-Chloro-5-methoxy-4-pyridinyl)boronic acid
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Methoxypyridine-4-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive cross-coupling applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.