Description

2-Fluoro-4-Methylpyridine-5-Boronic Acid is a high-purity, multi-functional boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in the synthesis of complex molecules, enabling the formation of carbon-carbon bonds via the versatile Suzuki-Miyaura cross-coupling reaction. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used to construct novel pyridine-based herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Material Science Research: Employed in the development of organic electronic materials, including ligands for OLEDs and charge-transport layers.
• Chemical Biology & Probe Development: Facilitates the creation of fluorinated molecular probes and tags for studying biological systems and enzyme activity.
• Cross-Coupling Reactions: Serves as a versatile boronic acid partner in Suzuki-Miyaura cross-coupling for constructing biaryl and heterobiaryl systems.
• Ligand Synthesis for Catalysis: Used to prepare sophisticated pyridine-containing ligands for transition metal catalysis.

Basic Information

Product Name	2-Fluoro-4-Methylpyridine-5-Boronic Acid
CAS No.	1072944-18-3
Molecular Formula	C6H7BFNO2
Molecular Weight	154.94 g/mol
Synonyms	(2-Fluoro-4-methylpyridin-5-yl)boronic acid; 5-Borono-2-fluoro-4-methylpyridine; 2-Fluoro-4-methyl-5-pyridineboronic acid; 4-Methyl-2-fluoro-5-pyridineboronic acid; 2-Fluoro-4-picoline-5-boronic acid; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-fluoro-4-methylpyridine (pinacol ester precursor)
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-4-Methylpyridine-5-Boronic Acid is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. Our standard grade meets typical research and development specifications, with comprehensive Certificates of Analysis (COA) provided for each lot, detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable and can support development projects requiring regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.