Description

Rho Kinase Inhibitor V CAS NO 1072906-02-5 is a potent and selective small molecule inhibitor of Rho-associated protein kinase (ROCK), a key regulator of the actin cytoskeleton and cell motility. This compound is a critical research tool for investigating signaling pathways involved in cell contraction, migration, and proliferation, with significant implications for cardiovascular and neurological research. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on drug discovery for conditions such as hypertension, glaucoma, and cancer metastasis.

Application

• Biomedical Research: A fundamental tool for studying Rho/ROCK signaling pathways in cellular and molecular biology experiments.
• Drug Discovery & Development: Used as a reference standard and pharmacological probe in high-throughput screening and lead optimization for cardiovascular and CNS disorders.
• Academic Studies: Enables investigation into the role of ROCK in smooth muscle contraction, neuronal axon guidance, and endothelial cell function.
• Preclinical Research: Employed in animal models to validate therapeutic hypotheses related to pulmonary hypertension, cerebral vasospasm, and corneal wound healing.
• Signal Transduction Analysis: Serves as a specific inhibitor to dissect the contribution of ROCK activity in complex cellular signaling networks.

Basic Information

Product Name	Rho Kinase Inhibitor V
CAS No.	1072906-02-5
Molecular Formula	C19H18N4O2S
Molecular Weight	366.44 g/mol
Synonyms	ROCK Inhibitor V; (S)-2-(3-(4-((4-Aminophenyl)amino)quinazolin-2-yl)phenoxy)-N-hydroxyacetamide; SAR407899; SAR-407899; (S)-N-Hydroxy-2-(3-(4-(4-phenylamino)quinazolin-2-yl)phenoxy)acetamide; (S)-2-[3-[4-(4-Aminophenylamino)quinazolin-2-yl]phenoxy]-N-hydroxyacetamide
EINECS	Contact for details

Quality Control

Our Rho Kinase Inhibitor V is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity confirmation and identity verification by spectroscopic methods, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed batch-specific data are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.