Description

Ethyl 2-Bromo-5-Fluoroisonicotinate is a high-purity fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. This compound is valued for its dual functionalization, offering both bromo and fluoro substituents for selective cross-coupling and further derivatization reactions. It is primarily sought by pharmaceutical and agrochemical R&D sectors for the development of novel active ingredients and complex molecular scaffolds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Material Science: Building block for creating functionalized ligands, organic semiconductors, and liquid crystal materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions.
• Fluorination Chemistry: Serves as a starting material for further fluorination or as a source of a fluoropyridine moiety in medicinal chemistry.
• Chemical Synthesis: Versatile intermediate for synthesizing more complex heterocyclic compounds and fine chemicals.

Basic Information

Product Name	Ethyl 2-Bromo-5-Fluoroisonicotinate
CAS No.	1072206-72-4
Molecular Formula	C8H7BrFNO2
Molecular Weight	248.05 g/mol
Synonyms	Ethyl 2-Bromo-5-fluoropyridine-4-carboxylate; 2-Bromo-5-fluoro-4-pyridinecarboxylic acid ethyl ester; 4-Pyridinecarboxylic acid, 2-bromo-5-fluoro-, ethyl ester; 5-Fluoro-2-bromoisonicotinic acid ethyl ester; Ethyl 5-fluoro-2-bromoisonicotinate; 2-Bromo-5-fluoropyridine-4-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 2-Bromo-5-Fluoroisonicotinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.