Description

Desbutyl Bumetanide-D5 is a deuterated analog of the loop diuretic bumetanide, specifically labeled at five positions with deuterium atoms. This stable isotope-labeled compound is an essential reference standard and internal standard for precise quantitative analysis in bioanalytical and pharmacokinetic studies. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and analytical testing facilities engaged in method development and validation for drug metabolism and excretion profiling.

Application

• Primary use as a stable isotope-labeled internal standard for the accurate quantification of bumetanide in biological matrices (e.g., plasma, urine, serum) via LC-MS/MS.
• Critical component in pharmacokinetic (PK) and bioequivalence studies to ensure data reliability and regulatory compliance.
• Essential reference material for method development and validation in analytical chemistry laboratories.
• Used in metabolite identification and profiling studies to understand drug disposition.
• Supports doping control analysis in sports where bumetanide is a prohibited diuretic.
• Facilitates clinical research on diuretic efficacy and renal function.

Basic Information

Product Name	Desbutyl Bumetanide-D5
CAS No.	1072125-54-2
Molecular Formula	C₁₅H₁₅D₅N₂O₅S
Molecular Weight	~369.45 g/mol
Synonyms	Bumetanide-d5 (Desbutyl); 3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic-2,4,5,6,7-d5 Acid; 5-(Butylamino)-4-phenoxy-3-sulfamoylbenzoic-2,4,5,6,7-d5 Acid; 4-Phenoxy-3-sulfamoyl-5-(butylamino)benzoic-2,4,5,6,7-d5 Acid; Bumetanide (phenyl-d5); Bumetanide-d5 (4-phenoxy ring); Deuterated Bumetanide Internal Standard; [2,4,5,6,7-d5]-Bumetanide
EINECS	Contact for details

Quality Control

Our Desbutyl Bumetanide-D5 is manufactured under strict quality control protocols to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for isotopic purity, chemical purity, and identity confirmation. We adhere to relevant industry standards for reference materials to support GLP/GMP-compliant research.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the product label or COA. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0% (Chemical Purity)
Isotopic Purity (MS)	≥98.0 atom % D
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.