Description

Cyc-065 CAS NO 1070790-89-4 is a potent and selective small molecule inhibitor of cyclin-dependent kinase 2 (CDK2) and CDK9, which are key regulators of the cell cycle and transcription. This compound is of significant interest for its role in disrupting the proliferation of cancer cells, particularly those dependent on specific oncogenic pathways. It is primarily utilized by researchers and developers in the pharmaceutical and biotechnology sectors for target validation, preclinical drug discovery, and as a reference standard in oncology research.

Application

• Oncology Research: Used as a chemical probe to study CDK2/9 inhibition and its effects on cell cycle arrest and apoptosis in various cancer cell lines.
• Drug Discovery & Development: Serves as a key intermediate or reference compound in the synthesis and optimization of novel CDK inhibitors for therapeutic applications.
• Biochemical Assays: Employed in high-throughput screening (HTS) and enzymatic assays to evaluate the potency and selectivity of new drug candidates targeting CDKs.
• Mechanistic Studies: Facilitates research into transcriptional regulation, DNA damage response, and the role of CDKs in diseases beyond cancer.
• Academic Research: A vital tool for universities and research institutes investigating fundamental cell biology and signal transduction pathways.

Basic Information

Item	Detail
Product Name	Cyc-065
CAS No.	1070790-89-4
Molecular Formula	C₂₀H₂₀N₈O₂
Molecular Weight	404.42 g/mol
Synonyms	Cyc065; SNS-032 Analog; CDK2/9 Inhibitor; (S)-6-(2-(Dimethylamino)ethyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-amine; 2-((2S)-2-aminopyrrolidin-1-yl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidine-4-carboxamide; Seliciclib Analog
EINECS	Contact for details

Quality Control

Our Cyc-065 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research use. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, identity, and purity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a desiccator to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.