Description

3-Fluoropyridine-2-Boronic Acid is a versatile and high-value organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling the efficient construction of complex fluorinated heterocycles via cross-coupling reactions, such as the Suzuki-Miyaura reaction. This compound is critically needed by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, including kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used to create novel fluorinated pesticides and herbicides with enhanced biological activity and environmental stability.
• Material Science Research: Serves as a building block for developing fluorinated liquid crystals, organic semiconductors, and metal-organic frameworks (MOFs).
• Suzuki-Miyaura Cross-Coupling: The primary application, facilitating carbon-carbon bond formation to attach the pyridine moiety to aryl or heteroaryl halides.
• Chemical Biology & Probe Development: Utilized in creating fluorinated molecular probes and tags for studying biological systems.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial production of fine chemicals.

Basic Information

Product Name	3-Fluoropyridine-2-Boronic Acid
CAS No.	1070774-29-6
Molecular Formula	C5H5BFNO2
Molecular Weight	140.91 g/mol
Synonyms	(3-Fluoropyridin-2-yl)boronic acid; 2-Borono-3-fluoropyridine; 3-Fluoro-2-pyridineboronic acid; 3-Fluoropyridine-2-boronic acid pinacol ester (common derivative); 3-Fluoro-2-pyridinylboronic acid; 3-Fluoropyridin-2-ylboronic Acid; 3-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (protected form); 1070774-29-6 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 3-Fluoropyridine-2-Boronic Acid is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR (1H, 11B, 19F), and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our clients in regulated development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Assay (NMR)	≥95.0%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.