Description

2-Chloro-4-Fluoropyridine-n-Oxide is a versatile and highly functionalized heterocyclic building block, specifically a halogenated pyridine N-oxide derivative. Its unique structure, featuring both chloro and fluoro substituents on the pyridine ring, makes it a critical intermediate for introducing specific molecular complexity in advanced synthesis. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors who require precise structural motifs for developing new active ingredients. Its reactivity profile allows for selective functionalization, enabling the creation of novel compounds with targeted properties.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Serves as a crucial building block for the manufacture of advanced herbicides, fungicides, and insecticides, where the fluorine and chlorine atoms enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for transition metal catalysis, facilitating challenging cross-coupling and other synthetic transformations.
• Material Science Precursor: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials that require specific halogenated heterocyclic components.
• Custom Synthesis and Contract Manufacturing: A fundamental starting material for custom chemical synthesis services, supporting R&D projects across multiple industries.
• Chemical Research & Development: A valuable reagent in academic and industrial laboratories for exploring new reaction methodologies and constructing complex molecular libraries.

Basic Information

Product Name	2-Chloro-4-Fluoropyridine-n-Oxide
CAS No.	1069098-61-8
Molecular Formula	C5H3ClFNO
Molecular Weight	147.54 g/mol
Synonyms	2-Chloro-4-fluoropyridine 1-oxide; 4-Fluoro-2-chloropyridine N-oxide; 2-Chloro-4-fluoropyridine N-oxide; Pyridine, 2-chloro-4-fluoro-, 1-oxide; 2-Chloro-4-fluoropyridine oxide
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Fluoropyridine-n-Oxide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity, potency, and impurity profiles. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ISO standards for industrial and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.