Description

Wortmannin-Rapamycin Conjugate CAS NO 1067892-47-0 is a potent, cell-permeable chemical probe designed for the dual inhibition of PI3K and mTOR signaling pathways. This conjugate is a critical research tool for investigating the complex crosstalk between these pathways in cellular processes such as growth, proliferation, and autophagy. It is primarily utilized by pharmaceutical researchers, academic scientists, and biotechnology companies engaged in oncology, metabolic disease, and aging research.

Application

• Mechanistic Research: Elucidating the interplay between PI3K/Akt and mTOR signaling networks in disease models.
• Oncology Studies: Investigating the effects of dual pathway inhibition on cancer cell proliferation, survival, and tumor growth.
• Autophagy Research: A key tool for studying the regulation of autophagy and its role in cellular homeostasis and disease.
• Biochemical Assay Development: Serving as a reference standard or active control in high-throughput screening (HTS) and in vitro kinase assays.
• Signal Transduction Analysis: Used in cell-based studies to dissect downstream effects of concurrent PI3K and mTOR inhibition.
• Preclinical Proof-of-Concept: Supporting early-stage drug discovery for therapeutic areas where PI3K/mTOR pathway dysregulation is implicated.

Basic Information

Product Name	Wortmannin-Rapamycin Conjugate
CAS No.	1067892-47-0
Molecular Formula	C58H81N3O14
Molecular Weight	1052.3 g/mol
Synonyms	PI-103; Wortmannin-Rapamycin Hybrid; PI3K/mTOR Dual Inhibitor; PIK-90; mTOR/PI3K Inhibitor; 17-Hydroxywortmannin-rapamycin Conjugate; SF1126 related agent; Chemical Probe for PI3K and mTOR
EINECS	Contact for details

Quality Control

Our Wortmannin-Rapamycin Conjugate is manufactured under strict quality protocols to ensure batch-to-batch consistency and reliability for critical research. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, potency, and analytical data is provided with every shipment to support your regulatory and documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.