Description

5-(2-Carboxyethenyl)-2-Methoxyphenyl β-D-Glucopyranosiduronic Acid is a high-purity, specialized glucuronide metabolite of significant interest in advanced pharmaceutical research and development. This compound serves as a critical reference standard and intermediate for the synthesis and analysis of drug metabolites, enabling precise pharmacokinetic and metabolic pathway studies. It is primarily utilized by research institutions, pharmaceutical companies, and CROs (Contract Research Organizations) focused on drug discovery, bioanalytical method development, and regulatory compliance testing.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and identification of drug metabolites in biological matrices via LC-MS/MS and HPLC.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for investigating the glucuronidation pathways of drug candidates, a major Phase II metabolism route.
• Bioanalytical Method Development: Serves as a critical standard for validating analytical methods to ensure accuracy, precision, and specificity in metabolite detection.
• Impurity Profiling: Employed in the identification and characterization of glucuronide-related impurities in active pharmaceutical ingredients (APIs).
• Preclinical and Clinical Research: Supports toxicology studies and clinical trial sample analysis to understand metabolite formation and clearance.
• Synthetic Intermediate: Used in the custom synthesis of more complex metabolite analogs or labeled (e.g., deuterated) standards for internal use.

Basic Information

Product Name	5-(2-Carboxyethenyl)-2-Methoxyphenyl β-D-Glucopyranosiduronic Acid
CAS No.	1065272-10-7
Molecular Formula	C₁₆H₁₈O₁₀
Molecular Weight	370.31 g/mol
Synonyms	2-Methoxy-5-vinylbenzoic acid β-D-glucuronide; (E)-3-(4-Methoxy-3-((2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-((carboxy)oxy)tetrahydro-2H-pyran-2-yl)phenyl)acrylic acid; Glucuronide metabolite of (E)-3-(4-Methoxy-3-hydroxyphenyl)acrylic acid; 5-[(1E)-2-Carboxyethenyl]-2-methoxyphenyl β-D-glucopyranosiduronic acid; A glucuronide conjugate of a methoxycinnamic acid derivative.
EINECS	Contact for details

Quality Control

Every batch of 5-(2-Carboxyethenyl)-2-Methoxyphenyl β-D-Glucopyranosiduronic Acid is manufactured and analyzed under strict quality management systems. Our products undergo rigorous identity, purity, and impurity profile testing using advanced techniques like HPLC, LC-MS, and NMR to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment to guarantee traceability and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This compound is hygroscopic (moisture-sensitive); therefore, containers should be sealed under inert atmosphere or with desiccant when opened to maintain stability and purity. For long-term storage, consider freezing at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.