Description

(+)-9-Deme-Dtbz CAS NO 1065193-59-0 is a high-purity, chiral pharmaceutical intermediate and reference standard of significant interest in advanced organic synthesis. This compound is valued for its role as a key building block in the research and development of novel active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. It is primarily sought after by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in process development and analytical method validation.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the multi-step synthesis of complex drug candidates.
• Reference Standard: Used for analytical method development, validation, and quality control (QC) in pharmaceutical analysis.
• Metabolite Studies: Employed in pharmacokinetic and metabolic pathway research for related pharmaceutical compounds.
• Asymmetric Synthesis: Serves as a valuable starting material or reagent in stereoselective chemical transformations.
• Academic & Industrial Research: Utilized in medicinal chemistry programs for structure-activity relationship (SAR) studies.
• Impurity Standard: Acts as a certified reference material for identifying and quantifying related substances in API batches.

Basic Information

Item	Details
Product Name	(+)-9-Deme-Dtbz
CAS No.	1065193-59-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(+)-9-Demethyl-DTBZ; (2S,3R,11bR)-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol; 9-O-Desmethyl Dihydrotetrabenazine (+)-isomer; Dihydrotetrabenazine derivative; AV-133 related compound
EINECS	Contact for details

Quality Control

Our (+)-9-Deme-Dtbz is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral purity analysis, and identity confirmation (IR, MS), to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.