Description

8-Chloro-6-(trifluoromethyl)quinolin-4(1H)-one is a high-value, fluorinated quinoline derivative that serves as a critical advanced intermediate in modern synthetic chemistry. Its unique structure, featuring both chloro and trifluoromethyl substituents, makes it an essential building block for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought after by research institutions and industrial R&D departments focused on medicinal chemistry, crop protection, and materials science.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of potential drug candidates, particularly in antiviral, anticancer, and anti-inflammatory research programs.
• Agrochemical Development: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and stability.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, cyclizations, and other transformations to construct complex heterocyclic systems.
• Material Science Research: Investigated as a precursor for organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components in organic light-emitting diodes (OLEDs).
• Chemical Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	8-Chloro-6-(trifluoromethyl)quinolin-4(1H)-one
CAS No.	1065092-49-0
Molecular Formula	C10H5ClF3NO
Molecular Weight	247.60 g/mol
Synonyms	8-Chloro-6-(trifluoromethyl)-1,4-dihydroquinolin-4-one; 8-Chloro-6-(trifluoromethyl)-4-hydroxyquinoline; 4-Hydroxy-8-chloro-6-(trifluoromethyl)quinoline; 8-Chloro-6-trifluoromethyl-4-quinolinol; 1065092-49-0; Quinolin-4(1H)-one, 8-chloro-6-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 8-Chloro-6-(trifluoromethyl)quinolin-4(1H)-one is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, impurity profile, and residual solvents. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your most critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and away from moisture and direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.