Description

5-Chloro-3-Fluoro-2-Nitropyridine is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters because its unique halogen and nitro substitution pattern offers versatile reactivity for constructing complex molecular architectures. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Material Science Precursor: Serves as a building block for functionalized ligands and organic electronic materials due to its electron-withdrawing nitro group.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions, enabling the introduction of diverse aryl and alkyl groups.
• Nucleophilic Aromatic Substitution: The chlorine and fluorine atoms provide distinct sites for selective displacement with various nucleophiles, facilitating scaffold diversification.
• Chemical Research & Development: A valuable tool compound for medicinal chemistry and process chemistry research in academic and industrial laboratories.

Basic Information

Product Name	5-Chloro-3-Fluoro-2-Nitropyridine
CAS No.	1064783-29-4
Molecular Formula	C5H2ClFN2O2
Molecular Weight	176.53 g/mol
Synonyms	2-Nitro-5-chloro-3-fluoropyridine; 3-Fluoro-5-chloro-2-nitropyridine; 5-Chloro-3-fluoro-2-nitropyridine; Pyridine, 5-chloro-3-fluoro-2-nitro-; 1064783-29-4
EINECS	Contact for details

Quality Control

Our 5-Chloro-3-Fluoro-2-Nitropyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with each shipment, detailing all specification results. We support cGMP compliance for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.