Description

4-Fluorophenylsulphur Pentafluoride is a specialized organosulfur fluoride compound with the CAS number 1063625-86-4, serving as a versatile building block in advanced chemical synthesis. Its unique structure, featuring a pentafluorosulfur (SF5) group attached to a fluorinated aromatic ring, makes it a high-value reagent for introducing both fluorine and the highly electronegative SF5 moiety into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors, where it is used to modulate the physicochemical properties of lead compounds, enhancing metabolic stability, lipophilicity, and bioavailability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of CNS drugs and anti-infectives where the SF5 group can improve blood-brain barrier penetration and metabolic resistance.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides, where the introduction of fluorine and sulfur pentafluoride groups can significantly enhance pesticidal activity and environmental stability.
• Material Science Research: Employed in the development of specialty polymers, liquid crystals, and electronic materials that require high thermal stability and unique dielectric properties.
• Fluorination Reagent: Acts as a source of the SF5 group in organic synthesis for the preparation of SF5-substituted arenes and heteroarenes, a growing area in medicinal and materials chemistry.
• Life Science Probes: Potential use in the design of PET (Positron Emission Tomography) tracer molecules and other diagnostic agents due to the presence of fluorine-19.

Basic Information

Product Name	4-Fluorophenylsulphur Pentafluoride
CAS No.	1063625-86-4
Molecular Formula	C6H4F6S
Molecular Weight	222.15 g/mol
Synonyms	Pentafluoro(4-fluorophenyl)sulfurane; 1-Fluoro-4-(pentafluoro-λ6-sulfanyl)benzene; 4-Fluorophenylsulfur pentafluoride; (4-Fluorophenyl)sulfur pentafluoride; SF5-Benzene, 4-fluoro-; p-Fluorophenylsulfur pentafluoride; 4-Fluoro-1-(pentafluoro-λ6-sulfanyl)benzene; 4-Fluoro-SF5-Benzene
EINECS	Contact for details

Quality Control

Our 4-Fluorophenylsulphur Pentafluoride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR (1H, 19F, 13C), GC-MS, and HPLC, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting critical parameters such as assay purity and impurity profiles. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your most sensitive synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (argon or nitrogen) after opening. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 97.0%
Purity (HPLC)	≥ 96.5%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.