Description

1-(Difluoromethoxy)-4-Iodo-2-Methylbenzene is a high-purity, specialized fluorinated and iodinated aromatic building block. This compound is valued for its unique molecular structure, which combines halogenated substituents to enable precise modifications in advanced chemical synthesis. It is primarily sought by research and development teams in the pharmaceutical and agrochemical sectors for creating novel active ingredients and intermediates. Its role is critical in medicinal chemistry for structure-activity relationship (SAR) studies and in material science for developing specialty polymers.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS and metabolic diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides, leveraging the difluoromethoxy and iodo groups for bioactivity.
• Material Science Precursor: Serves as a monomer or functionalization agent in the production of specialty polymers and liquid crystals with tailored electronic properties.
• Chemical Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Sonogashira) and nucleophilic aromatic substitution due to the reactive iodine atom.
• Positron Emission Tomography (PET) Tracer Development: The iodine-127 isotope provides a stable analog for developing radioiodinated (I-124, I-131) diagnostic imaging agents.
• Organic Electronics: Investigated as a component in the synthesis of organic semiconductors and charge-transport materials.

Basic Information

Product Name	1-(Difluoromethoxy)-4-Iodo-2-Methylbenzene
CAS No.	1062613-63-1
Molecular Formula	C8H7F2IO
Molecular Weight	284.05 g/mol
Synonyms	4-Iodo-2-methyl-1-(difluoromethoxy)benzene; 2-Methyl-4-iodo-1-(difluoromethoxy)benzene; 1-Difluoromethoxy-4-iodo-2-methylbenzene; Benzene, 1-(difluoromethoxy)-4-iodo-2-methyl-; 4-Iodo-α,α-difluoro-2-cresol methyl ether
EINECS	Contact for details

Quality Control

Our 1-(Difluoromethoxy)-4-Iodo-2-Methylbenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR, IR, and Mass Spectrometry. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications. Our quality commitment supports applications requiring high-purity building blocks for sensitive synthetic pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.