Description

(±)-Venlafaxine-D6 HCl is a deuterated internal standard of the widely prescribed serotonin-norepinephrine reuptake inhibitor (SNRI), Venlafaxine. This high-purity, isotopically labeled compound is essential for achieving precise and reliable quantification in bioanalytical studies, ensuring data integrity and regulatory compliance. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetics, metabolism research, and therapeutic drug monitoring.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard in LC-MS/MS and GC-MS methods for the accurate measurement of Venlafaxine and its metabolites in biological matrices like plasma, serum, and urine.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Drug Metabolism Studies: Used to investigate metabolic pathways and identify metabolites, aiding in drug development and safety profiling.
• Therapeutic Drug Monitoring (TDM): Supports the development and validation of robust assays for monitoring Venlafaxine levels in patients to optimize dosage and efficacy.
• Forensic Toxicology: Employed in confirmatory analytical procedures for the detection and quantification of Venlafaxine in forensic casework.
• Reference Standard for Quality Control: Acts as a certified reference material for calibrating instruments and validating analytical methods in quality control laboratories.

Basic Information

Product Name	(±)-Venlafaxine-D6 HCl
CAS No.	1062606-12-5
Molecular Formula	C17H21D6NO2 • HCl
Molecular Weight	319.87 g/mol (for free base C17H21D6NO2)
Synonyms	Venlafaxine-d6 hydrochloride; 1-[2-(Dimethyl-d6)-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride; (±)-1-[2-(Dimethylamino-d6)-1-(4-methoxyphenyl)ethyl]cyclohexanol HCl; DL-Venlafaxine-d6 HCl; O-Desmethylvenlafaxine-d6 precursor; Effexor-d6 internal standard; Deuterated Venlafaxine HCl
EINECS	Contact for details

Quality Control

Every batch of (±)-Venlafaxine-D6 HCl is manufactured and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing purity, isotopic enrichment, and impurity profiles to ensure it meets the exacting standards for use as an internal standard. Our products are suitable for use in GLP/GMP-compliant environments, supporting regulatory submissions and high-stakes research.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.