Description

Ldn-193189 Hcl is a potent and selective small molecule inhibitor of the BMP (Bone Morphogenetic Protein) type I receptors ALK2 and ALK3. This compound is a critical research tool for modulating the BMP signaling pathway, which plays essential roles in cellular differentiation, development, and tissue homeostasis. It is primarily utilized by researchers and scientists in the fields of developmental biology, stem cell research, and oncology to investigate disease mechanisms and potential therapeutic targets.

Application

• Stem Cell Research & Differentiation: Used to inhibit BMP signaling to promote the maintenance of pluripotency in embryonic stem cells or to direct differentiation into specific lineages.
• Developmental Biology Studies: Essential for investigating the role of BMP pathways in embryonic development and organogenesis.
• Cancer Research: Employed in preclinical studies to explore the involvement of BMP signaling in tumor progression, metastasis, and drug resistance.
• Bone & Cartilage Disease Models: Applied in research models for osteoporosis, heterotopic ossification, and osteoarthritis to understand BMP's anabolic and catabolic roles.
• Chemical Biology & Pathway Analysis: Serves as a precise pharmacological tool to dissect complex signaling networks and validate targets in vitro and in vivo.
• High-Throughput Screening (HTS): Used as a reference compound or positive control in screening assays designed to discover new BMP pathway modulators.

Basic Information

Product Name	Ldn-193189 Hcl
CAS No.	1062368-62-0
Molecular Formula	C₂₆H₂₆N₆O₂ • HCl
Molecular Weight	482.99 g/mol
Synonyms	LDN-193189 hydrochloride; LDN193189 HCl; DM-3189; 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline hydrochloride; BMP Inhibitor LDN-193189; ALK2/ALK3 Inhibitor; Dorsomorphin analog LDN-193189; BMP Type I Receptor Inhibitor II
EINECS	Contact for details

Quality Control

Our Ldn-193189 Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure identity, potency, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.