Description

Ldn-193189 is a potent and selective small molecule inhibitor of the BMP (Bone Morphogenetic Protein) type I receptors ALK2 and ALK3. This compound is a critical research tool for studying BMP signaling pathways, which are fundamental to developmental biology, stem cell differentiation, and various disease mechanisms. It is primarily utilized by researchers and scientists in the fields of academic research, pharmaceutical R&D, and biotechnology for target validation and pathway analysis.

Application

• Biomedical Research: A key reagent for investigating the role of BMP signaling in cell fate determination, organogenesis, and tissue regeneration.
• Stem Cell Studies: Used to direct the differentiation of pluripotent stem cells by selectively inhibiting BMP pathways to promote specific lineages.
• Drug Discovery: Serves as a pharmacological tool for target validation in preclinical models of diseases where BMP signaling is implicated, such as fibrodysplasia ossificans progressiva (FOP) and certain cancers.
• Developmental Biology: Employed in model organisms to elucidate the function of BMP receptors during embryonic development.
• Biochemical Assays: Used in high-throughput screening (HTS) and in vitro kinase assays to identify and characterize novel BMP pathway modulators.

Basic Information

Product Name	Ldn-193189
CAS No.	1062368-24-4
Molecular Formula	C₂₆H₂₆N₄O₃
Molecular Weight	442.51 g/mol
Synonyms	LDN193189; LDN-193189; DM-3189; 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline; DM3189; BMP Inhibitor LDN-193189; ALK2/3 Inhibitor LDN193189; Dorsomorphin analog LDN-193189
EINECS	Contact for details

Quality Control

Our Ldn-193189 is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. Certificates of Analysis (COA) detailing all quality parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	Yellow to light brown solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.