Description

Anacetrapib-D3 is a deuterium-labeled analog of the cholesteryl ester transfer protein (CETP) inhibitor anacetrapib, specifically designed for use as an internal standard in quantitative bioanalytical studies. This high-purity stable isotope-labeled compound is essential for ensuring accuracy and reliability in pharmacokinetic, metabolism, and clinical research. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in advanced drug development and regulatory compliance testing.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) methods for the precise quantification of anacetrapib in biological matrices such as plasma, serum, and tissues.
• Pharmacokinetic (PK) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical trials.
• Drug Metabolism Research: Used in metabolite identification and profiling studies to distinguish drug-derived compounds from endogenous substances.
• Clinical Trial Support: Provides method validation support for bioanalytical assays required in Phase I-IV clinical studies for cardiovascular therapeutics.
• Quality Control in Manufacturing: Can be employed in analytical method development for quality control of the active pharmaceutical ingredient (API).
• Regulatory Submissions: Supports data packages submitted to regulatory agencies (e.g., FDA, EMA) by ensuring the robustness and reproducibility of analytical data.

Basic Information

Product Name	Anacetrapib-D3
CAS No.	1061715-90-9
Molecular Formula	C30H27D3F6N3O2
Molecular Weight	582.56 g/mol (deuterated form)
Synonyms	(4S,5R)-5-[3,5-Bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-2'-methoxy-5'-(propan-2-yl)-4-(trifluoromethyl)[1,1'-biphenyl]-2-yl]methyl}-4-methyl-1,3-oxazolidin-2-one-d3; Deuterated Anacetrapib; Anacetrapib Internal Standard; Anacetrapib-d3; MK-0859-d3; CETP Inhibitor-d3
EINECS	Contact for details

Quality Control

Every batch of Anacetrapib-D3 is manufactured and analyzed under strict quality management protocols to ensure identity, purity, and isotopic enrichment meet the exacting standards required for bioanalytical applications. Comprehensive testing includes chromatographic purity (HPLC), isotopic purity (MS), and structural confirmation (NMR). A Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 99.0% D3
Chemical Purity	≥ 95.0%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.