Description

Cereblon Ligand 1 is a high-purity, small-molecule PROTAC (PROteolysis TArgeting Chimera) linker and degrader component. This compound is critical for targeted protein degradation research, enabling the study of novel therapeutic pathways by recruiting the E3 ubiquitin ligase cereblon. It is essential for pharmaceutical R&D, biotechnology, and academic laboratories focused on developing next-generation therapeutics for oncology, immunology, and neurodegenerative diseases.

Application

• PROTAC Molecule Synthesis: A key building block for constructing bifunctional degraders targeting specific proteins of interest.
• Chemical Biology Research: Used as a tool compound to study cereblon-mediated ubiquitination and protein degradation mechanisms.
• Drug Discovery & Development: Integral to preclinical research for novel targeted cancer therapies and treatments for immune disorders.
• Biopharmaceutical R&D: Employed in high-throughput screening and structure-activity relationship (SAR) studies to optimize degrader efficacy.
• Academic Research: Supports fundamental research in ubiquitin-proteasome system (UPS) biology and targeted protein degradation.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in degrader production.

Basic Information

Product Name	Cereblon Ligand 1
CAS No.	1061605-21-7
Molecular Formula	C₁₄H₁₀F₂N₄O₃
Molecular Weight	320.25 g/mol
Synonyms	Lenalidomide-based Cereblon Ligand; (S)-1-((2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)-3,3-difluoro-2-hydroxypropan-2-yl)carbamate; Thalidomide Derivative; IMiD-based Ligand; E3 Ligase Ligand 1; CRBN Ligand; PROTAC Linker for Cereblon; CC-885 analogue
EINECS	Contact for details

Quality Control

Every batch of Cereblon Ligand 1 is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) detailing purity (typically ≥95% by HPLC), confirming compliance with research-grade standards. Our quality protocols are designed to support GMP-ready applications in drug development.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, consider storage at 2-8°C under an inert atmosphere. Keep the container sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.