Description

1-(2-(Trifluoromethyl)Pyridin-4-Yl)Ethanone is a high-purity fluorinated pyridine derivative, serving as a critical advanced pharmaceutical intermediate and organic synthesis building block. Its unique trifluoromethylpyridine scaffold is essential for modulating the lipophilicity, metabolic stability, and bioavailability of target molecules in drug discovery. This compound is primarily required by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and fungicides, leveraging the biological activity of the trifluoromethylpyridine moiety.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers and advanced organic electronic materials.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel ligands for catalytic systems.
• Chemical Biology Probes: Utilized in the design of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis and Contract Manufacturing: A starting material for bespoke synthesis projects in fine chemical production.

Basic Information

Product Name	1-(2-(Trifluoromethyl)Pyridin-4-Yl)Ethanone
CAS No.	1060810-86-7
Molecular Formula	C8H6F3NO
Molecular Weight	189.14 g/mol
Synonyms	4-Acetyl-2-(trifluoromethyl)pyridine; 2-(Trifluoromethyl)-4-acetylpyridine; 1-[2-(Trifluoromethyl)-4-pyridinyl]ethanone; Ethanone, 1-[2-(trifluoromethyl)-4-pyridinyl]-; 4-Acetyl-2-trifluoromethylpyridine; 2-Trifluoromethyl-4-acetylpyridine; 1-(2-Trifluoromethylpyridin-4-yl)ethan-1-one
EINECS	Contact for details

Quality Control

Our 1-(2-(Trifluoromethyl)Pyridin-4-Yl)Ethanone is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and internal quality standards. Our commitment to cGMP principles ensures reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.