Description

4-Fluoro-Pyridine-3-Sulfonyl Chloride is a versatile and reactive organosulfur compound that serves as a critical building block in advanced organic synthesis. Its value lies in the combination of the pyridine heterocycle, a fluorine substituent, and the highly electrophilic sulfonyl chloride group, enabling precise molecular construction. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for creating sulfonamide and sulfonate derivatives.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those containing sulfonamide pharmacophores.
• Agrochemical Synthesis: Used in the research and production of modern herbicides, fungicides, and insecticides that require fluorinated pyridine scaffolds.
• Material Science Research: Employed in the development of specialty polymers, ligands for catalysis, and advanced functional materials.
• Chemical Biology & Proteomics: Acts as a reactive handle for bioconjugation and the development of chemical probes targeting specific enzymes or proteins.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	4-Fluoro-Pyridine-3-Sulfonyl Chloride
CAS No.	1060809-59-7
Molecular Formula	C5H3ClFNO2S
Molecular Weight	195.60 g/mol
Synonyms	3-Pyridinesulfonyl chloride, 4-fluoro-; 4-Fluoropyridine-3-sulfonyl chloride; 4-Fluoro-3-pyridinesulfonyl chloride; 4-Fluoro-3-sulfonylchloridopyridine; 1060809-59-7; 4-Fluoropyridine-3-sulfonic acid chloride
EINECS	Contact for details

Quality Control

Every batch of 4-Fluoro-Pyridine-3-Sulfonyl Chloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed results from HPLC, NMR, and IR spectroscopy. Our quality commitment ensures the material meets the stringent requirements for research and cGMP (current Good Manufacturing Practice) starting material applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.