Description

2-Fluoro-6-Methyl-Isonicotinic Acid CAS NO 1060806-00-9 is a high-purity fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic incorporation of fluorine and the carboxylic acid functional group, enabling precise modifications to molecular properties for enhanced bioactivity and material performance. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and fine-tuning the pharmacokinetic profiles of candidate molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), especially in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the fluorine atom can improve metabolic stability and membrane permeability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers and liquid crystals, where the isonicotinic acid core contributes to self-assembly and electronic properties.
• Chemical Biology Probes: Utilized as a building block for fluorescent tags and molecular probes used in diagnostic assays and cellular imaging.

Basic Information

Product Name	2-Fluoro-6-Methyl-Isonicotinic Acid
CAS No.	1060806-00-9
Molecular Formula	C7H6FNO2
Molecular Weight	155.13 g/mol
Synonyms	6-Methyl-2-fluoropyridine-4-carboxylic acid; 2-Fluoro-6-picolinic acid; 4-Carboxy-3-fluoro-6-methylpyridine; 2-Fluoro-6-methylisonicotinate (acid); 2-Fluoro-6-methyl-4-pyridinecarboxylic acid; Isonicotinic acid, 2-fluoro-6-methyl-; 1060806-00-9 (CAS)
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-6-Methyl-Isonicotinic Acid is manufactured under a strict quality management system and undergoes comprehensive analytical testing. We ensure compliance with stringent internal specifications, which are designed to meet the exacting requirements of research and process development. A detailed Certificate of Analysis (COA) confirming identity, purity (typically ≥97% by HPLC), and impurity profiles is provided with each shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.