Description

5-Fluoropyridine-3-Sulfonyl Chloride is a high-value, reactive organosulfur building block crucial for advanced chemical synthesis. This compound is specifically engineered to introduce the 5-fluoro-3-pyridinesulfonyl moiety, a key functional group in modern pharmaceutical and agrochemical development. It is primarily sought after by R&D chemists and process development scientists in the life sciences sector for constructing novel molecular entities with targeted biological activity.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the fluoropyridine scaffold for enhanced efficacy and selectivity.
• Chemical Biology & Proteomics: Serves as a versatile reagent for activity-based protein profiling (ABPP) and the development of covalent enzyme inhibitors.
• Material Science Research: Employed in the creation of functionalized polymers and advanced materials with specific surface properties.
• Sulfonamide Library Construction: A key reactant for high-throughput synthesis in medicinal chemistry to generate diverse sulfonamide-based compound libraries for screening.

Basic Information

Product Name	5-Fluoropyridine-3-Sulfonyl Chloride
CAS No.	1060802-49-4
Molecular Formula	C5H3ClFNO2S
Molecular Weight	195.60 g/mol
Synonyms	3-Pyridinesulfonyl chloride, 5-fluoro-; 5-Fluoro-3-pyridinesulfonyl chloride; 5-Fluoropyridine-3-sulfonyl chloride; 5-Fluoropyridin-3-ylsulfonyl chloride; 3-Chlorosulfonyl-5-fluoropyridine; 1060802-49-4; 5-Fluoro-3-sulfonylchloridopyridine
EINECS	Contact for details

Quality Control

Every batch of 5-Fluoropyridine-3-Sulfonyl Chloride is manufactured and tested under strict quality management protocols. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A detailed Certificate of Analysis (COA) including purity (HPLC), identity confirmation (NMR, IR), and impurity profile is supplied with each shipment to guarantee reproducible results and process reliability for our customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic and reactive nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to maintain stability and prevent hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.